| Chapters |
| Section I: Introduction |
| 1. |
The Vision and Mission of the Institute of Functional Medicine |
| 2. |
What is Functional Medicine? |
| 3. |
Why Functional Medicine? |
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3a. |
Importance of Improving Management of Complex, Chronic Disease |
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3b. |
Our Aging Population and the Centrality of Diet, Lifestyle and Environment |
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3c. |
Functional Medicine Incorporates Genomics |
| 4. |
Training Clinicians in the New Approaches to Care |
| 5. |
Changing the Evidence Model |
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5a. |
Functional Medicine and the Emerging Research Base |
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5b. |
Clinical Decision making - A Functional Medicine Perspective |
| Section II: Principles of Functional Medicine |
| 6. |
Functional Medicine is Science-Based |
| 7. |
Biochemical Individuality and Genetic Uniqueness |
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7a. |
Functional Medicine and Biochemical Individuality: A Paradigm Shift in Medicine |
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7b. |
Development of the Knowledge Base in Biochemical Individuality |
| 8. |
Patient-Centered Care: Antecedents, Triggers and Mediators |
| 9. |
Homeostasis: A Dynamic Balance |
| 10. |
Web-like Interconnections: The Complex Human Organism |
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10a. |
Web-like Interconnections of Physiological Factors |
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10b. |
Organ System Function and Underlying Mechanisms: The Interconnected Web |
| 11. |
Health as a Positive Vitality |
| 12. |
Healthy Aging: The Promotion of Organ Reserve |
| Section III: The Building Blocks |
| 13. |
Environmental Inputs |
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13a. |
Diet and Nutritents |
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13b. |
Air and Water |
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13c. |
Physical Exercise |
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13d. |
Psychosocial Influences |
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13e. |
Trauma |
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13f. |
Xenobiotics |
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13g. |
Micro-organisms |
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13h. |
Radiation |
| 14. |
Influence of Mind and Spirit |
| Section IV: Fundamental Physiological Processes |
| 15. |
Communications: Intracellular and Extracellular |
| 16. |
Bioenergetics and Biotransformation |
| 17. |
Digestion and Excretion |
| 18. |
Biology and Inflammation: A Common Pathway in Cardiovascular Disease, Part 1 |
| Section V: Fundamental Clinical Imbalances |
| 19. |
Hormonal Imbalances |
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19a. |
Female Hormones |
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19b. |
Male Hormones |
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19c. |
The Epidemic of Insulin Insensititivy |
| 20. |
Neurological Imbalances |
| 21. |
Oxidation-Reduction Imbalances |
| 22. |
Detoxification and Biotransformational Imbalances |
| 23. |
Immune Imbalances and Inflammation |
| 24. |
Digestive, Absorptive and Microbiological Imbalances |
| 25. |
Structural Imbalances |
| Section VI: A Practical Clinical Approach |
| 26. |
Clinical Approaches to Environmental Inputs |
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26a. |
Diet and Nutrition |
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26b. |
Micronutrient Insufficiency |
| 27. |
Clinical Approaches to Immune Imbalance and Inflammation |
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27a. |
Inflammation as a Precursor to CVD |
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27b. |
Inflammation and Autoimmunity: Nutrients and Botanicals as Anti-inflammatories |
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27c. |
Essential Fatty Acids |
| 28. |
Clinical Approaches to GI Imbalance |
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28a. |
Digestion and Absorption |
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28b. |
Balance of Flora, GALT and Mucosal Integrity |
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28c. |
The Enteric Nervous System |
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28d. |
The 4R Program |
| 29. |
Clinical Approaches to Structural Imbalance |
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29a. |
Physical Fitness and Exercise |
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29b. |
Maipulative Therapy and Functional Medicine: Clinical Interactions between Structure and Function |
| 30. |
Clinical Approaches to Energy Production and Oxidative Stress |
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30a. |
Bioenergetics, Mitochondrial Function and Oxidative Stress in Functional Medicine |
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30b. |
Oxidative Stress and Autism |
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30c. |
Oxidative Stress and Glycemic Control |
| 31. |
Clinical Approaches to Detoxification and Biotransformation |
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31a. |
Genetic and Environmental Influences on Detoxifcation |
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31b. |
Systemic In-Office Detoxification |
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31c. |
Home-Based Detoxification |
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31d. |
The Gut-Liver Axis |
| 32. |
Clinical Imbalances to Hormonal and Neuroendcrine Imbalances |
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32a. |
Cellular Messaging, Part 1 |
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32b. |
Cellular Messaging, Part 2 |
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32c. |
HPA Axis |
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32d. |
Insulin and Glucoregulatory Hormone Balance |
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32e. |
Perimenopause, Menopause and Women's Health |
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32f. |
Endometriosis and Fibroids |
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32g. |
Neurotransmitters |
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32h. |
Thyroid |
| 33. |
Stress, Spirituality, Poverty and Community - Effects on Health |
| Section VII: Putting It All Together |
| 34. |
The Patient's Story and the Clinician's Thinking - A Place to Start |
| 35. |
Assessment and Therapeutic Strategy - A Place to Start |
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35a. |
Elimination Diet and Laboratory Testing |
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35b. |
Identifying Practical Interventions that Help to Normalize Multiple Symptoms |
| 36. |
The Healing Relationship |
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36a. |
Effective Doctor-Patient Relationships |
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36b. |
Helping Patients to Change |
| 37. |
Case Presentation and Extended Discussion: Metabolic Syndrome, Cardiovascular Disease and Related Conditions |
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Authors |
| Jayne Alexander, DO |
DeAnn Liska, PhD |
| Bruce N. Ames, PhD |
Jay Lombard, MD |
| Peter Bennett, ND |
Dan Lukaczer, ND |
| Jeffrey S. Bland, PhD |
Micheel Lumpkin, PhD |
| John Cline, MD |
Michael Lyon, MD |
| Daniel Cosgrove, MD |
Sidney MacDonald Baker, MD |
| Walter J. Crinnion, ND |
Woody R. McGinnis, MD |
| Gary Darland, PhD |
Carol R. McMakin, MA, DC |
| Joel M. Evans, MD |
David Musnick, MD |
| William J. Evans, PhD |
Joseph E. Pizzorno, Jr., ND |
| Leo Galland, MD |
James O. Prochaska, PhD |
| Michael D. Gershon, MD |
Janice M. Prochaska, MSW, PhD |
| Patrick Hanaway, MD |
Sheila Quinn |
| Bethany Hays, MD |
Robert Roundtree, MD |
| Robert J. Hedaya, MD, FAPA |
Barb Schiltz, MD, RN |
Mark C. Houston, MD, MSc, SCH,
AGAAM, FACP, FAHA |
Virginia Shapiro, DC |
| Michael Stone, MD |
| Mark Hyman, MD |
Nancy Sudak, MD |
| Mary James, ND |
Thomas Sult, MD |
| David. S. Jones, MD |
Tom Sult, MD |
| Joseph J. Lamb, MD |
John Tatum, MD |
| Robert H. Lerman MD, PhD |
Alex Vasquez, DC, ND |
| Edward (Ted) Leyton, MD, CCFP |
David Wickes, DC |
| Petter Libby, MD |
Catherine Willner, MD |
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